Vaccines are a cornerstone of infectious disease prevention and a key strategy in reducing antimicrobial resistance (AMR). While mRNA vaccines have demonstrated rapid development and high efficacy, current formulations primarily protect against severe disease rather than preventing infection at mucosal entry points. This project aims to develop novel polymer-based nanoparticles for the non-viral delivery of mRNA vaccines directly to mucosal tissues, such as the respiratory tract. By leveraging high-throughput automated synthesis and formulation platforms, the project will generate and screen a diverse library of polymers optimised for mucosal delivery. The resulting delivery systems could enable next-generation vaccines that block infection at its source, with broad applicability to respiratory pathogens, including drug-resistant bacteria.
Approach and Methods:
- Use automated synthesis platforms to generate a high-throughput library of polymer candidates with varied physicochemical properties (charge, size, structure, biodegradability)
- Formulate polymer–mRNA nanoparticles and characterise their size, stability, and mucus-penetrating capabilities
- Evaluate delivery efficiency in cell-based models mimicking lung and immune tissues
- Identify structure–function relationships to inform rational design of future mucosal delivery systems
Impact and Outlook:
This project will establish a platform for the rapid development of non-viral mRNA delivery systems tailored for mucosal vaccination. The outcomes could significantly advance the field of respiratory vaccine development, enabling faster responses to emerging pathogens and reducing reliance on antibiotics through effective infection prevention.
Training and Student Development:
The student will gain interdisciplinary training in:
- Polymer and nanoparticle synthesis
- Laboratory automation and high-throughput screening
- Advanced characterisation techniques (e.g. DLS, TEM, UV-Vis, XRD)
- Cell culture and in vitro models of mucosal immunity
- Data analysis using Python and digital image processing
These skills are highly transferable to careers in biomedical research, pharmaceutical development, and biotechnology.
Research Environment:
The project is a collaboration between UCL Chemistry, Pharmacy, and Chemical Engineering departments. Students will work across multiple labs, benefiting from a multidisciplinary environment and access to cutting-edge facilities at UCL and the Royal Institution. The supervisory team offers strong mentorship and professional development opportunities, including support for publishing, conference participation, and career planning.
Desirable Prior Experience:
- Background in chemistry, pharmaceutical sciences, biomedical engineering, or materials science
- Experience with nanoparticle formulation, polymer chemistry, or cell culture is advantageous
- Interest in vaccine delivery, AMR, and translational biomedical research
Eligibility
UK Master's degree with Merit or a minimum upper second-class UK Bachelor's degree in a relevant discipline, or an overseas qualification of an equivalent standard. Relevant work experience may be considered.
Relevant disciplines include physics, chemistry, engineering, biology, mathematics, and related subjects.
Deadline: 12 January 2026
For more information and to apply visit https://www.findaphd.com/phds/project/high-throughput-optimisation-of-non-viral-delivery-systems-for-mucosal-mrna-vaccines-against-pathogenic-bacteria/?p191347
