This project is one of a number that are in competition for funding from the University of Bath URSA competition, for entry in September 2026.
A PhD opportunity is available to work with Prof. Simon Lewis and Dr James Taylor at the University of Bath on the development of new synthetic methodology for state-of-the-art radical chemistry.
Recent years have seen great progress in one-electron synthetic processes, i.e. radical chemistry. This has been enabled by methods that allow radicals to be generated and reacted in a controlled manner, e.g. photoredox catalysis. Another strategy for radical generation is to use Electron Donor-Acceptor (EDA) complexes; this approach is more recent and less developed. We propose to synthesise sulfonium salts that can form EDA complexes, which upon visible light irradiation will generate synthetically useful radical intermediates. These radicals will be able to effect late-stage functionalisation of complex molecules, e.g. for the synthesis of analogues of drug substances (which we will perform to demonstrate the usefulness of the reactions we have developed). The approach will be applicable not only for carbon-centred radicals, but also for heteroelements such as N, P and S-centred radicals. The sulfonium salts themselves will be prepared either using electrosynthesis, using “interrupted Pummerer” reactions, or using nucleophilic substitution approaches, depending on the group to be appended to sulfur. We anticipate the resulting sulfonium salts will be stable, crystalline substances that could ultimately be developed as commercial reagents.
This is an organic chemistry project focused on methodology development, which will give a student excellent all-round training in practical organic synthesis with particular emphasis on two contemporary techniques, electrosynthesis and photochemistry. They will also gain extensive experience of compound characterisation techniques (NMR, x-ray, possibly EPR, also HRMS, IR, UV/Vis etc.) and structural elucidation, as well as mechanistic investigations.
We are looking for an enthusiastic and motivated researcher to join our team. The student will benefit from joint supervision from two supervisors who, between them, have track records in all aspects of this project. The student will also benefit from wider training and development opportunities, including weekly problem sessions, departmental seminars, and attendance and participation at suitable conferences.
Project keywords: Synthesis; Electrosynthesis; Photochemistry; Electron-donor-acceptor complex
Candidate Requirements:
Applicants should hold, or expect to receive, a First Class or high Upper Second Class UK Honours degree (or the equivalent) in a relevant subject. A master’s level qualification would also be advantageous.
Non-UK applicants must meet the programme’s English language requirement by the application deadline.
Enquiries and Applications:
Informal enquiries are encouraged and should be directed to Prof Simon Lewis.
Application closing date: 8 February 2026
For more information and to apply visit https://www.findaphd.com/phds/project/radicals-on-demand-from-sulfonium-salt-electron-donor-acceptor-complexes/?p193379
