Peptides, beyond their essential role in biology and life processes, are also of significant importance in academic research and industry as bio-based, biodegradable components with diverse applications, including biomaterials, cosmetics, and pharmaceuticals. Their function in these environments is largely determined by supramolecular interactions, which are complex and challenging to predict, particularly in multicomponent systems. This collaborative project between few Dutch Universities and an Industrial Partner aims to address this challenge by developing advanced tools to understand and predict the properties of peptide-based materials.
The focus of this project is the synthesis and functionalization of peptide-based amphiphiles to establish a versatile materials platform for applications ranging from bio-based detergents to advanced biomaterials. Leveraging automated parallel peptide synthesis and purification systems, we will create libraries of short peptides and their derivatives. Special attention will be given to exploring N-mono- and N-bis-functionalized amino acids and other modifications using cutting-edge catalytic coupling methods. Additionally, the stereochemical aspects and biodegradability of the resulting compounds will be investigated.
Collaboration will be a key of this project, with opportunities to engage in joint experimental work within a dynamic research environment. By synthesizing and characterizing these materials, this research seeks to advance both fundamental understanding and practical applications in peptide-based systems.
The research program of the Feringa group is focused on synthetic and physical organic chemistry. Inspired by Nature’s principles of molecular assembly, recognition, transport, motion and catalysis, the goal is to exploit the full potential of synthetic chemistry to create new structures and functions. A major part of the research is directed towards dynamic molecular systems. The focus is on molecular nanoscience, novel responsive materials and photo-pharma exploring biohybrid systems, self-assembly, molecular switches and motors. A second part of the program deals with the development (and application in chemical biology) of novel stereoselective synthesis methods and asymmetric catalysis. Chirality is a leading theme and over the years a unique and broad expertise in fundamental aspects of stereochemistry has been acquired including chiroptical phenomena, chiral amplification and origin of chirality.
We are looking for candidates who meet the following requirements:
- A Masterās degree in chemistry or a related field.
- Knowledge and experience in synthetic organic chemistry; experience in peptide chemistry or supramolecular chemistry is an advantage.
- The ability to work independently and proactively, with strong problem-solving skills and self-motivation.
- A relevant academic record, including publications in peer-reviewed journals, is a plus.
Experience in peptide synthesis, stereochemistry, or catalysis will be considered an asset.
For more information and to apply visit https://www.rug.nl/about-ug/work-with-us/job-opportunities/?details=00347-02S000B4TP