We are currently seeking a Postdoctoral Research Associate to join our dynamic laboratory at the Rosalind Franklin Institute. If you are a creative scientist that want to explore novel venues on quantitative imaging biology, join us. The Pombo-Garcia lab is interested in Molecular Organisation of Cell Interfaces in the epithelial tissue and in pathology of intestinal diseases. We use super-resolution STED microscopy in combination with gut organoids, biophysics & chemical biology to uncover how epithelial cells organise in space and time under different physico-chemical environments to drive self-organisation processes that shape mesoscale structures enabling tissue function. To that end, we generate high amount of complex data across scales from molecules to mesoscale structures. Our interdisciplinary team includes biology, chemistry and physics.
The Franklin is building technologies to enable imaging molecules of interest in the context of disease in their native state, using electron microscopy, light and super-resolution correlative approaches. We provide cutting-edge infrastructure to develop and implement next generation tools to advance basic science and discovery of novel therapeutics. Your role will be to lead a research project focused on quantitative imaging of epithelial cell biology and biophysics. Moreover, to support and develop novel workflows of bioimaging analysis to quantify advanced imaging data generated by super-resolution STED microscopy, FLIM, FRET and FCS. You will collaborate with other research institutions including the University of Oxford.
Responsibilities
As a Postdoctoral Research Associate, your primary task will be to lead a project on quantitative imaging biology and you will:
- Develop novel ways of analysing complex data (eg. 3D volumetric STED) that will enable wider scientific discoveries and advance our understanding of biology.
- Contribute to the wider positive culture in the Franklin and will be expected to contribute intellectually to the development of groups at the Institute.
- Develop novel pipelines of generating quantitative bioimaging data using various optics and electronic tools.
- Contribute both to the development of new methods and their application to investigate the organisation and dynamics of cell interfaces, therefore applicants with a broad experimental-analytical interest are encouraged.
Candidates must hold a PhD qualification in cell biology, biophysics, physics, mathematics or computer science along with experience in advance quantitative microscopy analysis. We are looking for a colleague with strong organisational and communication skills, with demonstrated laboratory experience. Experience with formulating research questions and devising strategies to address these questions would aid the individual selected for this role. We expect you to lead publications, contribute to research grant writing, collaborate with other members of the lab towards knowledge advancement. This post would be ideal for a candidate who has developed a strong background on bioimaging analysis, quantitative biology or biophysics and would like to lead a project developing novel quantitative imaging pipelines and who would like to gain further experience in cutting edge techniques including super-resolution imaging, condensate biology and cell adhesion in epithelia tissue.
For more information and to apply visit https://opportunities.rfi.ac.uk/vacancy/pdra-in-quantitative-imaging-biology-577347.html