We recently developed a method for synthesis of otherwise difficult-to-access atropisomers by nucleophilic aromatic substitution. One advantage is that starting materials, NāH heterocycles and fluoroarenes, are readily available, and another is that the reactions are highly efficient and broadly applicable. However, the method currently produces racemates of atropisomers and is not catalytic. Accordingly, PhD students in our laboratory will develop catalytic atroposelective synthesis of such compounds and others. Several possibilities will be studied. The molecules synthesized in this project will be tested broadly in medicinal chemistry screenings.
PhD students must be enrolled in a partner university and will be employed by the IOCB Prague at the same time (part-time or full time), which results in a competitive salary (a scholarship from the university + a salary from the IOCB). Each university has its own process, terms, and deadlines for PhD applications, which is separate from the IOCB recruitment process. You may discuss the details with the respective PI.
For more information and to apply visit https://www.uochb.cz/en/open-positions/326/catalytic-synthesis-of-atropisomers-by-substitution