The talk will present the development and impact of a range of capabilities including microscale and nano scale HTE, and high-throughput electrochemistry. Innovations in synthetic chemistry across modalities (small molecules to macrocyclic peptides) with a lens toward medicinal chemistry applications will be described. In addition, the development of chemistry reaction machine learning models leveraging nanoscale HTE will be detailed.
Dr. Kalyani graduated from Bryn Mawr College, PA in 2003 with a B.A. in chemistry and mathematics and M.A. in computational chemistry. She received her Ph.D. in 2008 in organometallic catalysis under the supervision of Prof. Melanie Sanford at The University of Michigan, Ann Arbor. Following her Ph.D., she pursued her postdoctoral work under the guidance of Prof. Scott Denmark at University of Illinois at Urbana champaign in the field of asymmetric catalysis. In 2011, Dr. Kalyani started her independent career as an assistant professor in the chemistry department at St. Olaf College, MN and was granted tenure and promotion to Associate Professor in 2017. At St. Olaf College, Dr. Kalyani established an externally funded research program on organometallic catalysis and mentored ~60 undergraduate researchers. Her research was recognized by several awards including NSF CAREER grant, Cottrell Scholar award, ACS Young Investigator Award and Henry Dreyfus Teacher Scholar award.
In 2018, Dr. Kalyani transitioned from academia to Merck & Co., Inc as an Associate Principal Scientist in the High-Throughput Experimentation group in the Discovery Chemistry organization. In her current role, as a Principal Scientist Dr. Kalyani brings her passion for science and data rich experimentation to accelerate the drug discovery process leveraging a range of microscale and nanoscale HTE techniques.