This post represents an exciting opportunity for an ambitious individual to join a team of staff in Keele University’s Faculty of Natural Sciences. The faculty is responsible for the School of Chemical and Physical Sciences. A postdoctoral research associate position is available within the groups of Dr Sebastian C. Cosgrove &…
Allostery is a central mechanism for the regulation of multi-enzyme complexes. The mechanistic basis that drives allosteric regulation is poorly understood but harbors key information for enzyme engineering. In this talk, our new computational tools based on inter-residue correlations from microsecond time-scale Molecular Dynamics (MD) simulations and enhanced sampling techniques…
Keywords: Enzyme engineering, Biocatalysis, Artificial metalloenzymes, Chemo-enzymatic catalysis, Thermostability Expertise: My group has expertise in the design and engineering of enzymes with an expanded reaction scope, beyond what they have naturally evolved to catalyse. We apply genetic and chemical protein modification techniques, in order to modify the functionality of enzymes.…
